Catalog Number: 1206
Chemical Name: 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide
Biological Activity
Selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon.
    Botella et al.
    J.Pharmacol.Exp.Ther., 1995;273:1008
  2. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.
    Funk et al.
    J.Biol.Chem., 1993;268:26767
  3. Dibenzoxazepine hydrazides as prostaglandin antagonists.
    Intra-Science Chem.Rept., 1972;6:1

The citations listed below are publications that use Tocris products. Selected citations for SC 19220 include:

Showing Results 1 - 1 of 1

  1. Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland.
    Authors: Passafaro Et al.
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