SC 19220

Catalog # Availability Size / Price Qty
1206/10
1206/50
SC 19220 | CAS No. 19395-87-0 | Prostanoid Receptor Antagonists
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Description: Selective EP1 receptor antagonist

Chemical Name: 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells).

Technical Data

M.Wt:
331.76
Formula:
C16H14ClN3O3
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
19395-87-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon.
    Botella et al.
    J.Pharmacol.Exp.Ther., 1995;273:1008
  2. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.
    Funk et al.
    J.Biol.Chem., 1993;268:26767
  3. Dibenzoxazepine hydrazides as prostaglandin antagonists.
    Sanner
    Intra-Science Chem.Rept., 1972;6:1

Product Datasheets

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Citation for SC 19220

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SC 19220
By Anonymous on 05/31/2017
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