prostanoid receptor antagonist (Ki
values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μ
M for EP1
, TP, EP3
, FP and DP receptors respectively). Attenuates PGE2
-induced neuronal cell death in vitro
and slows tumor growth in vivo
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All Tocris products are intended for laboratory research use only.
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Effect of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice.
Saleem et al.
The utilization of recombinant prostanoid receptors determine the affinities and selectivities of prostaglandins and related analogs.
Abramovitz et al.
Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist.
Matsuo et al.