SC 51089

Catalog # Availability Size / Price Qty
3758/10
3758/50
SC 51089 | CAS No. 146033-02-5 | Prostanoid Receptor Antagonists
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Description: Selective EP1 receptor antagonist

Chemical Name: 8-Chlorodibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride

Purity: ≥99%

Product Details
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Biological Activity

Selective EP1 prostanoid receptor antagonist (Ki values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μM for EP1, TP, EP3, EP2, EP4, FP and DP receptors respectively). Attenuates PGE2-induced neuronal cell death in vitro and slows tumor growth in vivo.

Technical Data

M.Wt:
459.33
Formula:
C22H19ClN4O3.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
146033-02-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. The utilization of recombinant prostanoid receptors determine the affinities and selectivities of prostaglandins and related analogs.
    Abramovitz et al.
    Biochim.Biophys.Acta, 2000;1483:285
  2. Effect of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice.
    Saleem et al.
    J.Neurosci.Res., 2007;85:2433
  3. Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist.
    Matsuo et al.
    J.Neurochem., 2004;66:285

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