Catalog Number: 1550
Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Biological Activity
Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer.
    Daikoku et al.
    Cancer Res., 2005;65:3735
  2. COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events.
    Takeuchi et al.
    Curr.Top.Med.Chem., 2005;5:475
  3. Pharmacological analysis of cyclooxygenase-1 in inflammation.
    Smith et al.
    Proc Natl Acad Sci U S A, 1998;95:13313
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