Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Biological ActivitySC 560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer.
Daikoku et al.
Cancer Res., 2005;65:3735
COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events.
Takeuchi et al.
Pharmacological analysis of cyclooxygenase-1 in inflammation.
Smith et al.
Proc Natl Acad Sci U S A, 1998;95:13313
Citation for SC 560
The citations listed below are publications that use Tocris products. Selected citations for SC 560 include:
1 Citation: Showing 1 - 1
Prostaglandin-dependent modulation of DArgic neurotransmission elicits inflammation-induced aversion in mice.
Authors: Fritz Et al.
J Clin Invest 2016;126:695
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