SC 57461A

Key Product Details

Product Description

SC 57461A is a potent and selective inhibitor of LTA₄ hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC₄ synthase and 5-lipoxygenase. Potently inhibits LTB₄ production in whole blood (IC₅₀ = 49 nM). Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for SC 57461A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SC 57461A

The following data is based on the product molecular weight 363.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.74 mL	27.48 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Askonas Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A₄ hydrolase I: in vitro studies. J.Pharmacol.Exp.Ther. 2002 PMID: 11805219
• Kachur Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A₄ hydrolase II: in vivo studies. J.Pharmacol.Exp.Ther. 2002 PMID: 11805220
• Penning Synthesis of potent leukotriene A₄ hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. J.Med.Chem. 2002 PMID: 12139459

Product Documents for SC 57461A