SC 58125
Chemical Name: 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
Purity: ≥98%
Biological Activity
SC 58125 is a selective cyclooxygenase 2 (COX-2) inhibitor (IC50 values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
Gierse et al.
J.Biol.Chem., 1996;271:15810 -
A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts.
Williams et al.
Neoplasia, 2001;3:428 -
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Seibert et al.
Proc.Natl.Acad.Sci.USA, 1994;91:12013
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Citation for SC 58125
The citations listed below are publications that use Tocris products. Selected citations for SC 58125 include:
1 Citation: Showing 1 - 1
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CCL17 blockade as a therapy for osteoarthritis pain and disease.
Authors: Lee Et al.
Arthritis Res Ther 2018;20:62
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