Chemical Name: 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
Biological ActivitySC 58125 is a selective cyclooxygenase 2 (COX-2) inhibitor (IC50 values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
Gierse et al.
A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts.
Williams et al.
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Seibert et al.
Citation for SC 58125
The citations listed below are publications that use Tocris products. Selected citations for SC 58125 include:
1 Citation: Showing 1 - 1
CCL17 blockade as a therapy for osteoarthritis pain and disease.
Authors: Lee Et al.
Arthritis Res Ther 2018;20:62
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