SC 58125

Catalog # Availability Size / Price Qty
2895/10
2895/50
SC 58125 | CAS No. 162054-19-5 | Cyclooxygenase Inhibitors
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Description: Selective cyclooxygenase-2 (COX-2) inhibitor

Chemical Name: 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Selective cyclooxygenase 2 (COX-2) inhibitor (IC50 values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.

Technical Data

M.Wt:
384.35
Formula:
C17H12F4N2O2S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
162054-19-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
    Gierse et al.
    J.Biol.Chem., 1996;271:15810
  2. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts.
    Williams et al.
    Neoplasia, 2001;3:428
  3. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
    Seibert et al.
    Proc.Natl.Acad.Sci.USA, 1994;91:12013

Product Datasheets

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Citation for SC 58125

The citations listed below are publications that use Tocris products. Selected citations for SC 58125 include:

1 Citation: Showing 1 - 1

  1. CCL17 blockade as a therapy for osteoarthritis pain and disease.
    Authors: Lee Et al.
    Arthritis Res Ther  2018;20:62

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