Catalog Number: 2895
Chemical Name: 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
Biological Activity
Selective cyclooxygenase 2 (COX-2) inhibitor (IC50 values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
    Gierse et al.
    J.Biol.Chem., 1996;271:15810
  2. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts.
    Williams et al.
    Neoplasia, 2001;3:428
  3. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
    Seibert et al.
    Proc.Natl.Acad.Sci.USA, 1994;91:12013
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