Selective cyclooxygenase 2 (COX-2) inhibitor (IC50
values are 0.04 and >100 μ
M for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo
following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
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A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
Gierse et al.
A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts.
Williams et al.
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Seibert et al.