SCH 336

Key Product Details

Product Description

SCH 336 is a highly potent and selective CB₂ receptor inverse agonist (K_i = 1.8 nM, EC₅₀ = 2 nM). Displays 100-fold selectivity for CB₂ receptors over CB₁. Increases Forskolin stimulated cAMP accumulation in CHO cells expressing human CB₂ receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.

Product Specifications for SCH 336

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SCH 336

The following data is based on the product molecular weight 539.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.27 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lunn A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 2006 PMID: 16258021

Product Documents for SCH 336