SCH 336

Catalog # Availability Size / Price Qty
5815/50
5815/10
SCH 336 | CAS No. 447459-51-0 | Cannabinoid R2 / CB2 Inverse Agonists
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Description: Highly potent and selective CB2 inverse agonist

Chemical Name: N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide

Purity: ≥98%

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Biological Activity

Highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.

Technical Data

M.Wt:
539.64
Formula:
C23H25NO8S3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
447459-51-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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