SCH 58261

Key Product Details

Product Description

SCH 58261 is a potent and selective A_2A adenosine receptor competitive antagonist (K_i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A₁, A_2B and A₃ receptors, respectively. Reduces melanoma tumor growth and TGF-β levels in WT and P2X7R-null mice.

Product Specifications for SCH 58261

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SCH 58261

The following data is based on the product molecular weight 345.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.48 mL	28.96 mL
5 mM	0.58 mL	2.90 mL	5.79 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 213 publications citing the usage of this product.

• De Marchi A2A receptor contributes to tumor progression in P2X7 null mice. Front.Cell Dev.Biol. 2022 PMID: 35663396
• Bastia Effects of A₁ and A_2A adenosine receptor ligands in mouse acute models of pain. Neurosci.Lett. 2002 PMID: 12147316
• Belardinelli The A_2A adenosine receptor mediates coronary vasodilation. J.Pharmacol.Exp.Ther.
• Zocchi Binding of the radioligand [³H]-SCH 58261, a new non-xanthine A_2A adenosine receptor antagonist, to rat striatal membranes. J.Pharmacol.Exp.Ther. 1996 PMID: 8632302

Product Documents for SCH 58261