SCH 58261 (CAS 160098-96-4): R&D Systems
Catalog Number: 2270
Chemical Name: 2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Biological Activity
Potent and selective A2A adenosine receptor competitive antagonist (Ki = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
Technical Data
  • M.Wt:
    345.36
  • Formula:
    C18H15N7O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    160098-96-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes.
    Zocchi et al.
    J.Pharmacol.Exp.Ther., 1996;276:398
  2. Effects of A1 and A2A adenosine receptor ligands in mouse acute models of pain.
    Bastia et al.
    Neurosci.Lett., 2002;328:241
  3. The A2A adenosine receptor mediates coronary vasodilation.
    Belardinelli et al.
    J.Pharmacol.Exp.Ther., 1997;284:1066
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SCH 58261 include:

24 Citations: Showing 1 - 10
Filter your results:

  1. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction.
    Authors: Nadal Et al.
    Cancer Biol Ther 2016;9:67
  2. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    Psychopharmacology (Berl) 2015;35:621
  3. Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity.
    Authors: Kermanian Et al.
    J Neuroinflammation 2015;28:120
  4. On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
    Authors: Wydra Et al.
    Mol Brain 2015;232:1767
  5. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
    Authors: Perez-Aso Et al.
    Arthritis Res Ther 2015;17:249
  6. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods 2015;12:661
  7. Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.
    Authors: Madeira Et al.
    J Neurosci 2015;12:115
  8. Expression and characterization of purinergic receptors in rat middle meningeal artery-potential role in migraine.
    Authors: Haanes and Edvinsson
    Med J Islam Repub Iran 2014;9:e108782
  9. Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion.
    Authors: Häusler Et al.
    Neuroscience 2014;6:129
  10. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.
    Authors: Augusto Et al.
    Proc Natl Acad Sci U S A 2013;33:11390
  11. Opiate-induced changes in brain adenosine levels and narcotic drug responses.
    Authors: Wu Et al.
    J Neuroinflammation 2013;228:235
  12. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth.
    Authors: Mediavilla-Varela Et al.
    Am J Transl Res 2013;14:860
  13. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors.
    Authors: Hikida Et al.
    Nat Neurosci 2013;110:342
  14. Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis.
    Authors: Mills Et al.
    J Neurosci 2012;9:193
  15. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol 2012;86:10338
  16. When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
    Authors: Lee Et al.
    PLoS One 2012;7:e38865
  17. A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice.
    Authors: Teng and Mustafa
    J Exp Pharmacol 2011;2011:59
  18. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci 2010;13:958
  19. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci 2010;11:7
  20. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol 2009;47:684
  21. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence.
    Authors: Alam Et al.
    Mucosal Immunol 2009;2:232
  22. The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells.
    Authors: Wilson Et al.
    J Immunol 2009;182:4616
  23. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels.
    Authors: Guerreiro Et al.
    Mol Pharmacol 2008;74:980
  24. Dichotomous dopaminergic control of striatal synaptic plasticity.
    Authors: Shen Et al.
    Science 2008;321:848
Expand to show all 24 Citations

Have you used SCH 58261?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information