SCH 58261

  ( 30 citations )    
Product Datasheet
Catalog Number:2270
Chemical Name:2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Product Details
Citations (30)
Supplemental Products
Reviews
Biological Activity
Potent and selective A2A adenosine receptor competitive antagonist (Ki = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
Technical Data
  • M.Wt:
    345.36
  • Formula:
    C18H15N7O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    160098-96-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SCH 58261 include:

30 Citations: Showing 1 - 10
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  1. Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling.
    Authors: Xiong Et al.
    J Cell Biol  2017;216:761
  2. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction.
    Authors: Nadal Et al.
    Cancer Biol Ther  2016;9:67
  3. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    Psychopharmacology (Berl)  2015;35:621
  4. Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity.
    Authors: Kermanian Et al.
    J Neuroinflammation  2015;28:120
  5. On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
    Authors: Wydra Et al.
    Mol Brain  2015;232:1767
  6. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
    Authors: Perez-Aso Et al.
    Arthritis Res Ther  2015;17:249
  7. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods  2015;12:661
  8. Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.
    Authors: Madeira Et al.
    J Neurosci  2015;12:115
  9. Expression and characterization of purinergic receptors in rat middle meningeal artery-potential role in migraine.
    Authors: Haanes and Edvinsson
    Med J Islam Repub Iran  2014;9:e108782
  10. Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion.
    Authors: Häusler Et al.
    Neuroscience  2014;6:129
  11. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.
    Authors: Diógenes Et al.
    Cereb Cortex  2014;24:67
  12. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.
    Authors: Augusto Et al.
    Proc Natl Acad Sci U S A  2013;33:11390
  13. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils.
    Authors: Bao Et al.
    J Biol Chem  2013;288:22650
  14. Opiate-induced changes in brain adenosine levels and narcotic drug responses.
    Authors: Wu Et al.
    J Neuroinflammation  2013;228:235
  15. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth.
    Authors: Mediavilla-Varela Et al.
    Am J Transl Res  2013;14:860
  16. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors.
    Authors: Hikida Et al.
    Nat Neurosci  2013;110:342
  17. Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis.
    Authors: Mills Et al.
    J Neurosci  2012;9:193
  18. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol  2012;86:10338
  19. When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
    Authors: Lee Et al.
    PLoS One  2012;7:e38865
  20. Adenosine receptor signaling modulates permeability of the blood-brain barrier.
    Authors: Carman Et al.
    J Neurosci  2011;31:13272
  21. A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice.
    Authors: Teng and Mustafa
    J Exp Pharmacol  2011;2011:59
  22. Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine.
    Authors: Napolitano Et al.
    J Neurosci  2010;30:11043
  23. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  24. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci  2010;11:7
  25. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol  2009;47:684
  26. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence.
    Authors: Alam Et al.
    Mucosal Immunol  2009;2:232
  27. The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells.
    Authors: Wilson Et al.
    J Immunol  2009;182:4616
  28. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.
    Authors: Pugliese Et al.
    Br J Pharmacol  2009;157:818
  29. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels.
    Authors: Guerreiro Et al.
    Mol Pharmacol  2008;74:980
  30. Dichotomous dopaminergic control of striatal synaptic plasticity.
    Authors: Shen Et al.
    Science  2008;321:848
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