SCH 79797 dihydrochloride

  ( 25 citations )    
Product Datasheet
Catalog Number:1592
Chemical Name:N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
Product Details
Citations (25)
Supplemental Products
Reviews
Biological Activity
Potent, selective non-peptide PAR1 receptor antagonist (IC50 = 70 nM). Inhibits haTRAP-induced- but not γ-thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR1 agonist- or thrombin-induced increases in cytosolic Ca2+ in vascular smooth muscle cells.
Technical Data
  • M.Wt:
    444.41
  • Formula:
    C23H25N5.2HCl
  • Solubility:
    Soluble to 25 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    1216720-69-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SCH 79797 dihydrochloride include:

25 Citations: Showing 1 - 10
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  1. PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells.
    Authors: Zhang Et al.
    Mol Med Rep  2017;15:2595
  2. Interference with protease-activated receptor 1 alleviates neuronal cell death induced by lipopolysaccharide-stimulated microglial cells through the PI3K/Akt pathway
    Authors: Li Et al.
    Nature Communications  2016;6:38247
  3. PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo.
    Authors: Auvergne Et al.
    Oncogene  2016;35:3817
  4. Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells.
    Authors: Gwairi Et al.
    Int J Biol Sci  2016;12:1041
  5. Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.
    Authors: Carrim Et al.
    Proc Natl Acad Sci U S A  2015;6:640
  6. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
    Authors: Gur-Cohen Et al.
    Int J Oncol  2015;21:1307
  7. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci  2014;55:3912
  8. Thrombin conducts epithelial-mesenchymal transition via protease-activated receptor-1 in human gastric cancer.
    Authors: Otsuki Et al.
    J Biol Chem  2014;45:2287
  9. Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors.
    Authors: Yang Et al.
    Mediators Inflamm  2014;2013:165453
  10. Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination.
    Authors: Juncker-Jensen Et al.
    Cancer Res  2013;73:4196
  11. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage.
    Authors: Yan Et al.
    Nat Med  2013;44:1410
  12. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration.
    Authors: Gadepalli Et al.
    Redox Biol  2013;288:30815
  13. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
    Authors: Scarisbrick Et al.
    Cytotechnology  2012;393:355
  14. Thrombin activity associated with neuronal damage during acute focal ischemia.
    Authors: Chen Et al.
    J Neurosci  2012;32:7622
  15. Host gene-encoded severe lung TB: from genes to the potential pathways.
    Authors: Ganachari Et al.
    Genes Immun  2012;13:605
  16. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.
    Authors: Dowal Et al.
    J Neurosci  2011;108:2951
  17. A few immobilized thrombins are sufficient for platelet spreading.
    Authors: Okamura Et al.
    Biophys J  2011;100:1855
  18. Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion.
    Authors: Malik Et al.
    Cancer Res  2010;70:4327
  19. Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells.
    Authors: Yoshikawa Et al.
    Proc Natl Acad Sci U S A  2010;62:325
  20. Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells.
    Authors: Vidwan Et al.
    Arterioscler Thromb Vasc Biol  2010;30:2587
  21. Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.
    Authors: Lee Et al.
    J Immunol  2010;185:615
  22. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion.
    Authors: Fujimoto Et al.
    BMC Cancer  2010;10:443
  23. A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis.
    Authors: Blackburn Et al.
    Oncogene  2009;28:4237
  24. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
    Authors: Popovic Et al.
    J Leukoc Biol  2008;84:215
  25. Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.
    Authors: Ma Et al.
    Biol Chem  2005;102:216
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