SCH 79797 dihydrochloride

Catalog # Availability Size / Price Qty
1592/10
1592/50
SCH 79797 dihydrochloride | CAS No. 1216720-69-2 | Protease-Activated Receptor Antagonists
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Description: Potent, selective non-peptide PAR1 antagonist

Chemical Name: N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride

Purity: ≥99%

Product Details
Citations (26)
Supplemental Products
Reviews

Biological Activity

Potent, selective non-peptide PAR1 receptor antagonist (IC50 = 70 nM). Inhibits haTRAP-induced- but not γ-thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR1 agonist- or thrombin-induced increases in cytosolic Ca2+ in vascular smooth muscle cells.

Technical Data

M.Wt:
444.41
Formula:
C23H25N5.2HCl
Solubility:
Soluble to 25 mM in ethanol and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1216720-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SCH 79797 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SCH 79797 dihydrochloride include:

26 Citations: Showing 1 - 10

  1. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
    Authors: Noskovičová Et al.
    Am J Physiol Lung Cell Mol Physiol  2018;314:L695
  2. PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells.
    Authors: Zhang Et al.
    Mol Med Rep  2017;15:2595
  3. Interference with protease-activated receptor 1 alleviates neuronal cell death induced by lipopolysaccharide-stimulated microglial cells through the PI3K/Akt pathway
    Authors: Li Et al.
    Nature Communications  2016;6:38247
  4. PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo.
    Authors: Auvergne Et al.
    Oncogene  2016;35:3817
  5. Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells.
    Authors: Gwairi Et al.
    Int J Biol Sci  2016;12:1041
  6. Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.
    Authors: Carrim Et al.
    Proc Natl Acad Sci U S A  2015;6:640
  7. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
    Authors: Gur-Cohen Et al.
    Int J Oncol  2015;21:1307
  8. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci  2014;55:3912
  9. Thrombin conducts epithelial-mesenchymal transition via protease-activated receptor-1 in human gastric cancer.
    Authors: Otsuki Et al.
    J Biol Chem  2014;45:2287
  10. Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors.
    Authors: Yang Et al.
    Mediators Inflamm  2014;2013:165453
  11. Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination.
    Authors: Juncker-Jensen Et al.
    Cancer Res  2013;73:4196
  12. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage.
    Authors: Yan Et al.
    Nat Med  2013;44:1410
  13. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration.
    Authors: Gadepalli Et al.
    Redox Biol  2013;288:30815
  14. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
    Authors: Scarisbrick Et al.
    Cytotechnology  2012;393:355
  15. Thrombin activity associated with neuronal damage during acute focal ischemia.
    Authors: Chen Et al.
    J Neurosci  2012;32:7622
  16. Host gene-encoded severe lung TB: from genes to the potential pathways.
    Authors: Ganachari Et al.
    Genes Immun  2012;13:605
  17. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.
    Authors: Dowal Et al.
    J Neurosci  2011;108:2951
  18. A few immobilized thrombins are sufficient for platelet spreading.
    Authors: Okamura Et al.
    Biophys J  2011;100:1855
  19. Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion.
    Authors: Malik Et al.
    Cancer Res  2010;70:4327
  20. Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells.
    Authors: Yoshikawa Et al.
    Proc Natl Acad Sci U S A  2010;62:325
  21. Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells.
    Authors: Vidwan Et al.
    Arterioscler Thromb Vasc Biol  2010;30:2587
  22. Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.
    Authors: Lee Et al.
    J Immunol  2010;185:615
  23. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion.
    Authors: Fujimoto Et al.
    BMC Cancer  2010;10:443
  24. A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis.
    Authors: Blackburn Et al.
    Oncogene  2009;28:4237
  25. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
    Authors: Popovic Et al.
    J Leukoc Biol  2008;84:215
  26. Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.
    Authors: Ma Et al.
    Biol Chem  2005;102:216

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