SDZ WAG 994
Chemical Name: N-Cyclohexyl-2'-O-methyladenosine
Biological ActivityPotent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Adenosine receptors as therapeutic targets.
Jacobson and Gao
Nat.Rev.Drug Discov., 2006;5:247
Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia.
Ishikawa et al.
Diabetes Res.Clin.Pract., 1998;39:3
General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist.
Wagner et al.
Drug Dev.Res., 1995;34:276
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