SDZ WAG 994

Key Product Details

Product Description

SDZ WAG 994 is a potent and selective A₁ adenosine receptor agonist (K_i values are 23, > 10000 and 25000 nM for A₁, A_2A and A_2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (K_i = 8 nM).

Product Specifications for SDZ WAG 994

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SDZ WAG 994

The following data is based on the product molecular weight 363.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.76 mL	27.52 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
10 mM	0.28 mL	1.38 mL	2.75 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jacobson and Gao Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 2006 PMID: 16518376
• Wagner General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A₁ receptor agonist. Drug Dev.Res.
• Ishikawa Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A₁ receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 1998 PMID: 9597368

Product Documents for SDZ WAG 994