Semaglutide

Tocris Bioscience | Catalog # 8946

Highly potent, long-acting GLP-1 receptor agonist
Tocris Bioscience

Key Product Details

Description

Highly potent, long-acting GLP-1 receptor agonist
View all Glucagon-Like Peptide 1 Receptor Agonists »

Product Description

Semaglutide is a glucon-like peptide 1 analog and a potent and long-acting GLP-1R agonist. Upon activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, causing lasting and reversible weight loss in normal and obese rats.

Semaglutide enhances autophagy by increasing the expression of LC3II, Atg7, Beclin-1 and P62; inhibits oxidative stress and apoptosis. Semaglutide has neuroprotective properties in a stroke animal model, where neurogenesis and growth factor cell signaling is normalized.

Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.

Product Specifications for Semaglutide

Formula

C187H291N45O59

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

910463-68-2

PubChem ID

154733530

InChI Key

DLSWIYLPEUIQAV-CIIFZSTISA-N

SMILES

CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC(C(C)(NC([C@H](CC3=CNC=N3)N)=O)C)=O)CCC(O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CO)=O)CC5=CC=C(C=C5)O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Product Documents for Semaglutide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Semaglutide

For research use only

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