Semax

Tocris Bioscience | Catalog # 7712

Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide
Tocris Bioscience
Discontinued Product
7712 has been discontinued. View all TrkB products.

Key Product Details

Description

Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide
View all TrkB »

Product Description

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) (4-10). It increases hippocampal BDNF and TrkB expression and levels in vivo. Semax regulates cortical nitric oxide (NO) and lipid peroxidation and is neuroprotective in a rat model of global ischemia. Semax sequesters copper ions and interacts directly with Aβ:Cu2+ oligomers leading to reduced amyloid β protein (Aβ) aggregation and fibrillogenesis. Semax increases viability of d-SH-SY5Y cells pre-incubated with Aβ1-42 oligomers.

Product Specifications for Semax

Molecular Weight

813.93

Formula

C37H51N9O10S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

80714-61-0

PubChem ID

9811102

InChI Key

AFEHBIGDWIGTEH-AQRCPPRCSA-N

SMILES

O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(NCC(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Product Documents for Semax

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Semax

For research use only

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