Description: Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide
Biological ActivitySemax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) (4-10). It increases hippocampal BDNF and TrkB expression and levels in vivo. Semax regulates cortical nitric oxide (NO) and lipid peroxidation and is neuroprotective in a rat model of global ischemia. Semax sequesters copper ions and interacts directly with Aβ:Cu2+ oligomers leading to reduced amyloid β protein (Aβ) aggregation and fibrillogenesis. Semax increases viability of d-SH-SY5Y cells pre-incubated with Aβ1-42 oligomers.
Soluble to 2 mg/ml in water
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.