Catalog Number: 4875
Chemical Name: 4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
Biological Activity
Cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.
Technical Data
  • M.Wt:
    310.78
  • Formula:
    C17H14N4.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Senex Biotechnology.
Background References
  1. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
    Porter, Donald C, Farmaki, Elena, Altilia, Serena, Schools, Gary P, West, Deborah, Chen, Mengqian, Chang, Bey-Dih, Puzyrev, Anatoliy, Lim, Chang-uk, Rokow-Kittell, Rebecca, Friedhoff, Lawrence, Papavassiliou, Athanasi, Kalurupalle, Swathi, Hurteau, Gregory, Shi, Jun, Baran, Phil S, Gyorffy, Balazs, Wentland, Mark P, Broude, Eugenia, Kiaris, Hippokra, Roninson, Igor B
    Proc Natl Acad Sci U S A, 2012;109(34):13799-804.

Have you used Senexin A?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information