Catalog Number: 1068
Biological Activity
NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.
Technical Data
  • M.Wt:
    841.97
  • Formula:
    C40H55N7O11S
  • Sequence:
    DFFGLM

    (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in PBS (pH 7.4)
  • Storage:
    Desiccate at -20°C
  • CAS No:
    106128-89-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The selective NK receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro.
    Keegan et al.
    Br.J.Pharmacol., 1992;105:3
  2. Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide.
    Renzetti et al.
    Neuropeptides, 1991;18:107
  3. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils.
    Nordquist et al.
    Eur.J.Pharmacol., 2008;600:87
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Senktide include:

5 Citations: Showing 1 - 5
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  1. Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
    Authors: León Et al.
    Endocrinology 2016;6:19206
  2. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
    Authors: Navarro Et al.
    Nat Commun 2015;156:627
  3. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
    Authors: Grachev Et al.
    Cereb Cortex 2012;7:e44344
  4. Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex.
    Authors: Gallopin Et al.
    J Neurosci 2006;16:1440
  5. Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons.
    Authors: Howe Et al.
    Sci Rep 2004;24:10103

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