Catalog Number: 1068
Biological Activity
NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in PBS (pH 7.4)
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The selective NK receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro.
    Keegan et al.
    Br.J.Pharmacol., 1992;105:3
  2. Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide.
    Renzetti et al.
    Neuropeptides, 1991;18:107
  3. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils.
    Nordquist et al.
    Eur.J.Pharmacol., 2008;600:87
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