Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α
2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro
. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.
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Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Das et al.