Catalog Number: 2395
Chemical Name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
Biological Activity
Potent, orally active selective serotonin re-uptake inhibitor (SSRI); antidepressant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.
    Koe et al.
    J.Pharmacol.Exp.Ther., 1983;226:686
  2. Pharmacology of sertraline: a review.
    Heym and Koe
    J.Clin.Psychiatry, 1988;49:40
  3. Sertraline: a new antidepressant.
    Doogan and Caillard
    J.Clin.Psychiatry., 1988;49:46

The citations listed below are publications that use Tocris products. Selected citations for Sertraline hydrochloride include:

Showing Results 1 - 2 of 2

  1. Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis
    Authors: Lyons Et al.
    The journal of Neuroscience
  2. Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.
    Authors: Pai Et al.
    J Neurosci
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