Sertraline hydrochloride

Key Product Details

Product Description

Sertraline is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) that is an orally active antidepressant. Sertraline also decreases ergosterol biosynthesis and exhibits antifungal activity against Candida auris in vitro. Sertraline acts as an inhibitor of SHMT(serine hydroxymethyltransferase), inhibiting serine/glycine synthesis and proliferation of serine/glycine synthesis-dependent breast cancer cell lines in vitro and in vivo.

Product Specifications for Sertraline hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sertraline hydrochloride

The following data is based on the product molecular weight 342.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.59 mL	29.18 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Geeraerts Repurposing the antidepressant Sertraline as SHMT inhibitor to suppress serine/glycine synthesis-addicted breast tumor growth. Mol.Cancer Ther. 2021 PMID: 33203732
• Gowri Sertraline as a promising antifungal agent: inhibition of growth and biofilm of Candida auris with special focus on the mechanism of action in vitro. J.Appl.Microbiol. 2020 PMID: 31621139
• Heym and Koe Pharmacology of sertraline: a review. J.Clin.Psychiatry 1988 PMID: 3045112
• Doogan and Caillard Sertraline: a new antidepressant. J.Clin.Psychiatry. 1988 PMID: 2842321
• Koe Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J.Pharmacol.Exp.Ther. 1983 PMID: 6310078

Product Documents for Sertraline hydrochloride