Chemical Name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
Biological ActivitySertraline is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) that is an orally active antidepressant. Sertraline also decreases ergosterol biosynthesis and exhibits antifungal activity against Candida auris in vitro. Sertraline acts as an inhibitor of SHMT(serine hydroxymethyltransferase), inhibiting serine/glycine synthesis and proliferation of serine/glycine synthesis-dependent breast cancer cell lines in vitro and in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for Sertraline hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Sertraline hydrochloride include:
3 Citations: Showing 1 - 3
Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis
Authors: Lyons Et al.
The journal of Neuroscience 2016;36:7392
Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
Authors: Hooper Et al.
Am J Physiol Heart Circ Physiol 2016;311:H572
Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.
Authors: Pai Et al.
J Neurosci 2015;35:4366
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