Novel, potent and selective sphingosine-1-phosphate 1 (S1P1
) receptor agonist. Activates S1P1
receptor with an EC50
of 13 nM, but does not activate S1P2
receptors at concentrations up to 10 μ
M. Cell-permeable and active in vivo
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
Hale et al.
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.
Sanna et al.
Sphingosine-1-phosphate prevents tumor necrosis factor-α-mediated monocyte adhesion to aortic endothelium in mice.
Bolick et al.
The citations listed below are publications that use Tocris products. Selected citations for SEW 2871 include:
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