SGC AAK1 1

Tocris Bioscience | Catalog # 6528

AAK1 and BMP2K inhibitor; activates Wnt signaling
Tocris Bioscience

Key Product Details

Description

AAK1 and BMP2K inhibitor; activates Wnt signaling
View all Other Kinase Inhibitors »

Product Description

SGC AAK1 1 is an adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC50 values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.

Product Specifications for SGC AAK1 1

Molecular Weight

427.52

Formula

C21H25N5O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide

CAS Number

2247894-32-0

PubChem ID

134812845

InChI Key

UCBIQZUJJSVQHL-UHFFFAOYSA-N

SMILES

O=C(NC1=NNC2=C1C=CC(C3=CC=CC(NS(=O)(N(CC)CC)=O)=C3)=C2)C4CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.75 100

Preparing Stock Solutions for SGC AAK1 1

The following data is based on the product molecular weight 427.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.70 mL 23.39 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for SGC AAK1 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SGC AAK1 1

For research use only

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