SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

Name: SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]
Brand: Novus Biologicals
SKU: NBP2-74173B
Price: 699 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-74173B

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Product Documents

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Product Specifications
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine

Applications

Western Blot, Flow Cytometry

Label

Biotin

Antibody Source

Monoclonal Mouse IgG_2A Clone # OTI3F2

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Product Specifications

Immunogen

Full length recombinant protein of human SHP-2/PTPN11 (NP_002825) produced in HEK293T cells.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Applications for SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

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Advanced Features

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Antigen Density Selector - Match fluorochrome brightness with antigen density

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Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHP-2

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Long Name

Src Homology Region 2 Domain Phosphatase 2

Alternate Names

PTP1D, PTP2C, PTPN11, SH-PTP2, SHP2

Gene Symbol

PTPN11

Additional SHP-2 Products

Product Documents for SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

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Certificate of Analysis

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Product Specific Notices for SHP-2/PTPN11 Antibody (OTI3F2) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.