SHP-2/PTPN11 Antibody [Biotin]

Name: SHP-2/PTPN11 Antibody [Biotin]
Brand: Novus Biologicals
SKU: AF10121B
Price: 499 USD
Availability: InStock

Novus Biologicals | Catalog # AF10121B

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Goat IgG

View all SHP-2 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human SHP-2
Glu2-Thr435
Accession # Q06124

Specificity

Detects human, mouse, and rat SHP-2 in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for SHP-2/PTPN11 Antibody [Biotin]

Application

Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHP-2

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Long Name

Src Homology Region 2 Domain Phosphatase 2

Alternate Names

PTP1D, PTP2C, PTPN11, SH-PTP2, SHP2

Additional SHP-2 Products

Product Documents for SHP-2/PTPN11 Antibody [Biotin]

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Certificate of Analysis

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Product Specific Notices for SHP-2/PTPN11 Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.