SHU 9119

Name: SHU 9119
Brand: Tocris Bioscience
SKU: 3420
Price: 197 USD
Availability: InStock

Tocris Bioscience | Catalog # 3420

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Citations (36)

Product Documents

MC3 and MC4 antagonist; MC5 partial agonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

MC3 and MC4 antagonist; MC5 partial agonist

View all Additional Melanocortin Receptor Peptides »

Product Description

SHU 9119 is a potent melanocortin MC₃ and MC₄ receptor antagonist (IC₅₀ values are 0.23 and 0.06 nM respectively) and MC₅ partial agonist (EC₅₀ = 0.12 nM). Upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACCα and FAS), increases triglyceride synthesis and promotes insulin resistance. Increases food intake, body weight and fat mass when administered centrally in vivo.

Product Specifications for SHU 9119

Molecular Weight

1074.25

Formula

C₅₄H₇₁N₁₅O₉

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

168482-23-3

PubChem ID

9898183

InChI Key

GGYWLZFXFKFWKL-XOJVSUSESA-N

SMILES

CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

Grieco Further structure-activity studies with lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4 and 5. Peptides 2007 PMID: 17482720
Nogueiras The central melanocortin system directly controls peripheral lipid metabolism. J.Clin.Invest. 2007 PMID: 17885689
Hruby Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10] a-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency a J.Med.Chem. 1995 PMID: 7658432

Product Documents for SHU 9119

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for SHU 9119

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Nutrition and Appetite

Citations for SHU 9119

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