SHU 9119

  ( 1 citations )    
Product Datasheet
Catalog Number:3420
Chemical Name:
Product Details
Citations (1)
Supplemental Products
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Biological Activity
Potent melanocortin MC3 and MC4 receptor antagonist (IC50 values are 0.23 and 0.06 nM respectively) and MC5 partial agonist (EC50 = 0.12 nM). Upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACCα and FAS), increases triglyceride synthesis and promotes insulin resistance. Increases food intake, body weight and fat mass when administered centrally in vivo.
Technical Data
  • M.Wt:
    1074.25
  • Formula:
    C54H71N15O9
  • Sequence:
    XDHXRWK

    (Modifications: X-1 = Ac-Nle, X-4 = D-2-Nal, Lys-7 = C-terminal amide, cyclized Asp-2 - Lys-7)

  • Solubility:
    Soluble to 0.20 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    168482-23-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SHU 9119 include:

1 Citations: Showing 1 - 1

  1. Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.
    Authors: Tao and Huang
    Front Endocrinol (Lausanne)  2014;5:131

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