A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5
receptor subtype; displays an IC50
value of 0.3 μ
M� at hmGlu5
, compared with > 100 μ
M at hmGlu1b
. Centrally active upon systemic administration in vivo
. Positive allosteric modulator at mGlu4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Mathiesen et al.
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).
Chapman et al.
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
Varney et al.
The citations listed below are publications that use Tocris products. Selected citations for SIB 1893 include:
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