Catalog Number: 1214
Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
Biological Activity
A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 μM� at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.
Technical Data
  • M.Wt:
    195.26
  • Formula:
    C14H13N
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at +4°C
  • CAS No:
    6266-99-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
    Mathiesen et al.
    Br.J.Pharmacol., 2003;138:1026
  2. Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).
    Chapman et al.
    Neuropharmacology, 2000;39:1567
  3. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
    Varney et al.
    J.Pharmacol.Exp.Ther., 1999;290:170
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SIB 1893 include:

2 Citations: Showing 1 - 2
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  1. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
    Authors: Edri Et al.
    Nat Commun 2015;6:6500
  2. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
    Authors: Mathiesen Et al.
    Br J Pharmacol 2003;138:1026

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