SIB 1893
Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
Biological Activity
SIB 1893 is an a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 μM at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).
Chapman et al.
Neuropharmacology, 2000;39:1567 -
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Mathiesen et al.
Br.J.Pharmacol., 2003;138:1026 -
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
Varney et al.
J.Pharmacol.Exp.Ther., 1999;290:170
Product Datasheets
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Citations for SIB 1893
The citations listed below are publications that use Tocris products. Selected citations for SIB 1893 include:
2 Citations: Showing 1 - 2
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Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
Authors: Edri Et al.
Nat Commun 2015;6:6500
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Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Authors: Mathiesen Et al.
Br J Pharmacol 2003;138:1026
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