SIB 1893

Catalog # Availability Size / Price Qty
1214/10
1214/50
SIB 1893 | CAS No. 6266-99-5 | Group I mGluR Antagonists
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Description: mGlu5 antagonist; also positive allosteric modulator at mGlu4 receptors

Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine

Product Details
Citations (2)
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Biological Activity

A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 μM at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.

Technical Data

M.Wt:
195.26
Formula:
C14H13N
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
6266-99-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SIB 1893

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