Catalog Number: 3625
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
Biological Activity
Potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L.
    Shah et al.
    Mol.Pharmacol., 2008;74:34
  2. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.
    Myers et al.
    Bioorg.Med.Chem.Lett., 2008;18:210
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