Catalog Number: 3784
Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
Biological Activity
Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.
Technical Data
  • M.Wt:
    666.7
  • Formula:
    C22H30N6O4S.C6H8O7
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    171599-83-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.
    Ballard et al.
    J.Urol., 1998;159:2164
  2. Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds.
    Turko et al.
    Mol.Pharmacol., 1999;56:124
  3. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
    Ghofrani et al.
    Nat.Rev.Drug Discov., 2006;5:689
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sildenafil citrate include:

1 Citations: Showing 1 - 1

  1. The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems.
    Authors: Vandendriessche Et al.
    Development 2013;8:e72155

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