Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50
= 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro
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Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.
Ballard et al.
Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds.
Turko et al.
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
Ghofrani et al.
Nat.Rev.Drug Discov., 2006;5:689
The citations listed below are publications that use Tocris products. Selected citations for Sildenafil citrate include:
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