Sildenafil citrate

Catalog # Availability Size / Price Qty
Sildenafil citrate | CAS No. 171599-83-0 | Phosphodiesterase Inhibitors
1 Image
Description: Potent PDE5 inhibitor; orally active

Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
    Ghofrani et al.
    Nat.Rev.Drug Discov., 2006;5:689
  2. Effects of silde. on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.
    Ballard et al.
    J.Urol., 1998;159:2164
  3. Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. and related compounds.
    Turko et al.
    Mol.Pharmacol., 1999;56:124
  4. Viagra enables efficient, single-day hematopoietic stem cell mobilization.
    Smith-Berdan et al.
    Stem Cell Reports., 2019;
  5. Acetazolamide, nifedipine and phosphodiesterase inhibitors: rationale for their utilization as adjunctive countermeasures in the treatment of coronavirus disease 2019 (COVID-19).
    Solaimanzadeh et al.
    Cureus, 2020;12:e7343

Product Datasheets

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Citation for Sildenafil citrate

The citations listed below are publications that use Tocris products. Selected citations for Sildenafil citrate include:

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