Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
Biological ActivityOrally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
Ghofrani et al.
Nat.Rev.Drug Discov., 2006;5:689
Effects of silde. on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.
Ballard et al.
Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. and related compounds.
Turko et al.
Viagra enables efficient, single-day hematopoietic stem cell mobilization.
Smith-Berdan et al.
Stem Cell Reports., 2019;
Acetazolamide, nifedipine and phosphodiesterase inhibitors: rationale for their utilization as adjunctive countermeasures in the treatment of coronavirus disease 2019 (COVID-19).
Solaimanzadeh et al.
Citation for Sildenafil citrate
The citations listed below are publications that use Tocris products. Selected citations for Sildenafil citrate include:
1 Citation: Showing 1 - 1
The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems.
Authors: Vandendriessche Et al.
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