Simple Plex Human Periostin/OSF-2 Cartridge
R&D Systems | Catalog # SPCKB-PS-000522
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Key Product Details
Assay Length
Sample Type & Volume Required Per Well*
Sensitivity
Assay Range
Simple Plex Human Periostin/OSF-2 Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay's minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Compatible Instruments
Ella Automated Immunoassay System
Product Specifications
Assay Type
Format
Species
Specificity
Cross-reactivity
Interference
Precision
Intra-Assay Precision (Precision within an assay) Each control was tested multiple times in one Periostin/OSF-2 assay.
Inter-Assay Precision (Precision between assays) Replicates of each Periostin/OSF-2 control were tested in multiple assays performed by at least three technicians using two lots of reagents for human Periostin/OSF-2.
EDTA Plasma, Heparin Plasma, Serum
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 16 | 16 |
| Mean (pg/mL) | 822 | 45,723 | 816 | 44,667 |
| Standard Deviation | 37.8 | 3070 | 69.9 | 4520 |
| CV% | 4.6 | 6.7 | 8.6 | 10.1 |
Recovery for Simple Plex Human Periostin/OSF-2 Cartridge
Recovery was not necessary as human Periostin/OSF-2 shows 5 points of natural linearity.
Linearity
Samples containing and/or spiked with high concentrations of human Periostin/OSF-2 were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay.
Scientific Data Images for Simple Plex Human Periostin/OSF-2 Cartridge
Simple Plex Human Periostin/OSF-2 Assay Standard Curve
Data shown represents typical performance results for Lower Limit of Quantitation (LLOQ) and Upper Limit of Quantitation (ULOQ) for Simple Plex Human Periostin/OSF-2 Assay. Assay range is 15.7-150,000 pg/mL.Preparation and Storage
Shipping
Stability & Storage
Background: Periostin/OSF-2
Periostin, also known as OSF-2, is a secreted matricellular protein with functions in extracellular matrix formation, cell migration, and inflammation. It is secreted as a 90 kDa monomer that can aggregate into >170 kDa higher-order multimers. Periostin is expressed by mesenchymal cells such as vascular smooth muscle cells, fibroblasts, osteoblasts, and odontoblasts in developing teeth. It is upregulated in many carcinomas. Periostin binds to multiple Integrins and enhances cell adhesion and cell migration. It enhances Fibronectin and Collagen I production and promotes collagen fibrillogenesis. It also induces epithelial-mesenchymal transition, tumor growth, invasion, and metastasis. Periostin induces the expression of VEGF R2 on endothelial cells and VEGF-C in tumor cells, and it can induce tumor lymphangiogenesis. Periostin plays an important role in heart valve development and tissue healing after myocardial infarction. In asthma, it is upregulated in bronchial epithelium and plays both destructive and protective roles by inducing eosinophil infiltration and inhibiting goblet cell metaplasia and mucus production.
Long Name
Alternate Names
Gene Symbol
Additional Periostin/OSF-2 Products
Product Documents for Simple Plex Human Periostin/OSF-2 Cartridge
Certificate of Analysis
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Product Specific Notices for Simple Plex Human Periostin/OSF-2 Cartridge
For research use only
Related Research Areas
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