Simple Plex Mouse GDF-8/Myostatin Cartridge
R&D Systems | Catalog # SPCKB-MP-012979
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Simple Plex cartridges are custom built to fit your needs. Choose from over 350 assays spanning human, mouse, rat, and non-human primate. Just select your sample type, cartridge size (16, 32, or 72 samples), and up to 8 analytes per cartridge. Customize this cartridge.
Key Product Details
Assay Length
Sample Type & Volume Required Per Well*
Sensitivity
Assay Range
Simple Plex Mouse GDF-8/Myostatin Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay's minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Compatible Instruments
Ella Automated Immunoassay System
Product Specifications
Species
Specificity
Cross-reactivity
Interference
Sample Values
Precision
Intra-Assay Precision (Precision within an assay) Multiple replicates of each control were tested in one assay.
Inter-Assay Precision (Precision between assays) Replicates of each control were tested in multiple runs performed by at least three technicians using two lots of reagents.
EDTA Plasma, Heparin Plasma, Serum
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 68 | 65 |
| Mean (pg/mL) | 224 | 9507 | 140 | 6355 |
| Standard Deviation | 6.30 | 460 | 14.9 | 574 |
| CV% | 2.8 | 4.8 | 10.7 | 9.0 |
Recovery for Simple Plex Mouse GDF-8/Myostatin Cartridge
Recovery was not necessary as mouse GDF-8 shows 5 points of natural linearity.
Linearity
Samples containing and/or spiked with high concentrations of GDF-8 were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay.
Scientific Data Images for Simple Plex Mouse GDF-8/Myostatin Cartridge
Simple Plex Mouse GDF-8 Ella Assay Standard Curve
Preparation and Storage
Shipping
Stability & Storage
Background: GDF-8/Myostatin
GDF-8/Myostatin is a secreted protein that is expressed in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. It is upregulated in mechanically-stressed cardiomyocytes and induces the skeletal muscle wasting which is common in heart failure. The GDF-8 propeptide is cleaved from GDF-8 but remains associated and functions as an inhibitor of mature GDF-8. GDF-8 activity can also be inhibited through its association with Follistatin, FLRG, Decorin, or GASP-1. Active GDF-8 signals through a receptor complex containing Activin RIIB and either Activin RIB/ALK-4 or TGF-beta RI/ALK-5.
Long Name
Alternate Names
Gene Symbol
Additional GDF-8/Myostatin Products
Product Documents for Simple Plex Mouse GDF-8/Myostatin Cartridge
Certificate of Analysis
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Product Specific Notices for Simple Plex Mouse GDF-8/Myostatin Cartridge
For research use only
Related Research Areas
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