Simple Plex Rat TIM-1/KIM-1/HAVCR Cartridge
Simple Plex Rat TIM-1/KIM-1/HAVCR Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Product Summary
Precision
Cell Culture Supernates, Rat Serum, Rat EDTA Plasma, Rat Urine
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 21 | 19 |
| Mean (pg/mL) | 53.5 | 2476 | 50.9 | 2593 |
| Standard Deviation | 2.8 | 176 | 4.57 | 214 |
| CV% | 5.2 | 7.1 | 9 | 8.3 |
Recovery
| Sample Type | Average % Recovery | Range % |
|---|---|---|
| Rat EDTA Plasma (n=4) | 102 | 94-113 |
| Rat Serum (n=4) | 103 | 94-111 |
| Rat Urine (n=4) | 110 | 103-115 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: TIM-1/KIM-1/HAVCR
TIM-1 (T cell immunoglobulin and mucin domain 1), also known as KIM-1 and HAVcr1, is expressed on many immune cell types and epithelial cells. It binds to phosphatidylserine (PS), LMIR5/CD300b, TIM-1 (homophilic), TIM-4, IgA, and the glycoproteins of a number of enveloped viruses. Its interaction with PS enables TIM-1 to mediate the phagocytosis and clearance of apoptotic cells. TIM-1 signaling costimulates T cell activation and enhances Th2 cytokine production. TIM-1 serves as a cellular entry receptor for hepatitis A virus, Ebolavirus and Marburgvirus. Polymorphisms are associated with susceptibility to atopy, autoimmunity, and severe hepatitis A virus infection in humans. A soluble form of TIM-1 is elevated in the urine during nephropathy.
FAQs
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