SIS17

Key Product Details

Product Description

SIS17 is a selective HDAC11 inhibitor (IC₅₀ = 0.83 μM). Inhibits demyristoylation of serine hydroxymethyl transferase 2 with no detectable activity at other HDAC subtypes. Combination with Oxaliplatin (Cat. No. 2623) increases cytotoxicity to K562 cells; improves survival of Oxaliplatin-treated 769P cells. Cell permeable.

Product Specifications for SIS17

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SIS17

The following data is based on the product molecular weight 366.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.28 mL	136.38 mL	272.77 mL
0.5 mM	5.46 mL	27.28 mL	54.55 mL
1 mM	2.73 mL	13.64 mL	27.28 mL
5 mM	0.55 mL	2.73 mL	5.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 PMID: 35657209
• Son Activity-guided design of HDAC11-specific inhibitors. ACS Chem.Biol. 2019 PMID: 31264832

Product Documents for SIS17