Catalog Number: 2623
Alternate Names: Eloxatin
Chemical Name: Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Biological Activity
Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in water with gentle warming
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies.
    Culy et al.
    Drugs, 2000;60:895
  2. Cellular and molecular pharmacology of oxaliplatin.
    Raymond et al.
    Mol.Cancer Ther., 2002;1:227
  3. Oxaliplatin: a review of evolving concepts.
    Mani et al.
    Cancer Invest., 2002;20:246
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