Catalog Number: 2623
Alternate Names: Eloxatin
Chemical Name: Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Biological Activity
Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.
Technical Data
  • M.Wt:
    397.29
  • Formula:
    C8H14N2O4Pt
  • Solubility:
    Soluble to 5 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    61825-94-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies.
    Culy et al.
    Drugs, 2000;60:895
  2. Cellular and molecular pharmacology of oxaliplatin.
    Raymond et al.
    Mol.Cancer Ther., 2002;1:227
  3. Oxaliplatin: a review of evolving concepts.
    Mani et al.
    Cancer Invest., 2002;20:246
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Oxaliplatin include:

6 Citations: Showing 1 - 6
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  1. FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.
    Authors: Li Et al.
    BMC Cancer 2015;6:9240
  2. Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC.
    Authors: Massey
    PLoS One 2015;10:e0134306
  3. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
    Authors: Fukushima Et al.
    Cancer Sci 2015;106:1000
  4. Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.
    Authors: Bryant Et al.
    Exp Neurol 2014;14:570
  5. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen 2012;15:359
  6. Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline.
    Authors: Boyette-Davis and Dougherty
    Oncotarget 2011;229:353

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