Oxaliplatin

Tocris Bioscience | Catalog # 2623

DNA cross-linking antitumor agent
Tocris Bioscience

Key Product Details

Description

DNA cross-linking antitumor agent

Alternative Names

Eloxatin
View all Apoptosis Inducer Compounds »

Product Description

Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Product Specifications for Oxaliplatin

Molecular Weight

397.29

Formula

C8H14N2O4Pt

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)

CAS Number

61825-94-3

PubChem ID

9887054

InChI Key

ZROHGHOFXNOHSO-BNTLRKBRSA-L

SMILES

[Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.99 5 with gentle warming

Preparing Stock Solutions for Oxaliplatin

The following data is based on the product molecular weight 397.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 50.34 mL 251.71 mL 503.41 mL
0.25 mM 10.07 mL 50.34 mL 100.68 mL
0.5 mM 5.03 mL 25.17 mL 50.34 mL
2.5 mM 1.01 mL 5.03 mL 10.07 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 81 publications citing the usage of this product.

Product Documents for Oxaliplatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Oxaliplatin

For research use only

Customer Reviews for Oxaliplatin (2)

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  • Oxaliplatin induced immunogenic cell death in HCT116 cells
    Name: Tahmineh Safaie
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HCT116
    Verified Customer | Posted 02/28/2020
    HCT116 cells were treated with 600 uM of Oxaliplatin for 4 hours and up regulation of surface expression of calreticulin was measured.
    Oxaliplatin 2623
  • Oxaliplatin effectively kills melanoma cell growth in vitro
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/14/2019
    Oxaliplatin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
    Oxaliplatin 2623

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