SIS3

  ( 2 citations )    
Product Datasheet
Catalog Number:5291
Chemical Name:1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride
Product Details
Citations (2)
Reviews
Biological Activity
Selective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
Technical Data
  • M.Wt:
    489.99
  • Formula:
    C28H27N3O3.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    521984-48-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SIS3 include:

2 Citations: Showing 1 - 2
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  1. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  2. Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells.
    Authors: Echeverría Et al.
    J Cell Mol Med  2013;17:800

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