SJ 10542

Tocris Bioscience | Catalog # 7727

Potent and selective JAK2/3 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective JAK2/3 Degrader (PROTAC®)
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Product Description

SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC®) (DC50 values are 11 nM and 14 nM; Dmax = 92% and 90% for JAK3 and JAK2, respectively); uses a phenyl glutarimide ligand as the cereblon recruiter. Degrades JAK2 in ex vivo cell lines and patient derived xenografts (DC50= <120 nM) and displays high selectivity over GSPT1 and other members of the JAK family.

JAK3 antibody validated for Western Blot also available: Catalog # MAB4699.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Product Specifications for SJ 10542

Molecular Weight

818.96

Formula

C41H46N12O5S

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide

CAS Number

2789678-92-6

PubChem ID

162679331

InChI Key

WBEBZVDAHMXWJN-UHFFFAOYSA-N

SMILES

O=C(NC1=O)CCC1C2=CC=C(N3CCN(CCCNC(C4=CC=C(NC5=NC6=C(C=CN6)C(C7=CN(C8(CC#N)CN(S(CC)(=O)=O)C8)N=C7)=N5)C=C4)=O)CC3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.95 50

Preparing Stock Solutions for SJ 10542

The following data is based on the product molecular weight 818.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.44 mL 12.21 mL 24.42 mL
2.5 mM 0.49 mL 2.44 mL 4.88 mL
5 mM 0.24 mL 1.22 mL 2.44 mL
25 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SJ 10542

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJ 10542

For research use only

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