SJ 6986

Key Product Details

Product Description

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC₅₀ = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC₅₀ values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo, SJ 6986 is stable in mouse (t_1/2 = 4.7 h). This product is orally bioavailable.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Product Specifications for SJ 6986

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SJ 6986

The following data is based on the product molecular weight 497.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.05 mL	20.10 mL
5 mM	0.40 mL	2.01 mL	4.02 mL
10 mM	0.20 mL	1.01 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nishiguchi Identification of potent, selective, and orally bioavailable small- molecule GSPT1/2 degraders from a focused library of cereblon modulators. J.Med.Chem. 2021 PMID: 34042448

Product Documents for SJ 6986