SJFδ

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SJFδ | CAS No. 2254609-23-7 | Active Degraders
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Description: Potent and selective p38δ PROTAC®

Chemical Name: N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Purity: ≥98%

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Biological Activity

SJFδ is a potent and selective PROTAC ® Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1168.28
Formula:
C62H63F2N7O12S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2254609-23-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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