SJFδ

Key Product Details

Product Description

SJFδ is a potent and selective PROTAC ^® Degrader of p38δ (DC₅₀ = 46.17 nM; D_max = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for SJFδ

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SJFδ

The following data is based on the product molecular weight 1168.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.71 mL	8.56 mL	17.12 mL
2.5 mM	0.34 mL	1.71 mL	3.42 mL
5 mM	0.17 mL	0.86 mL	1.71 mL
25 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Smith Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat.Commun. 2019 PMID: 30631068

Product Documents for SJFδ