Chemical Name: 2-chloro-α-methyl-benzenepropanamine hydrochloride
Biological ActivitySK 609 is a dopamine D3 receptor biased agonist. Preferentially signals via the G protein-dependent pathway (EC50 values for G protein and β-arrestin-dependent signaling are 1.1 and 50.2 μM, respectively). Exhibits selectivity for D3 over D2 receptors. Improves motor deficits in rodent Parkinson's disease models and ameliorates L-DOPA (Cat. No. 3788) induced abnormal involuntary movements.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional characterization of a novel series of biased signaling dopamine D3 receptor agonists.
Xu et al.
ACS Chem.Neurosci., 2017;8:486
In vivo characterization of a novel dopamine D3 receptor agonist to treat motor symptoms of Parkinson's disease.
Simms et al.
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