SK 609

Key Product Details

Product Description

SK 609 is a dopamine D₃ receptor biased agonist. Preferentially signals via the G protein-dependent pathway (EC₅₀ values for G protein and β-arrestin-dependent signaling are 1.1 and 50.2 μM, respectively). Exhibits selectivity for D₃ over D₂ receptors. Improves motor deficits in rodent Parkinson's disease models and ameliorates L-DOPA (Cat. No. 3788) induced abnormal involuntary movements.

Product Specifications for SK 609

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SK 609

The following data is based on the product molecular weight 220.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.54 mL	22.71 mL	45.43 mL
5 mM	0.91 mL	4.54 mL	9.09 mL
10 mM	0.45 mL	2.27 mL	4.54 mL
50 mM	0.09 mL	0.45 mL	0.91 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Simms In vivo characterization of a novel dopamine D₃ receptor agonist to treat motor symptoms of Parkinson's disease. Neuropharmacology 2016 PMID: 25896768
• Xu Functional characterization of a novel series of biased signaling dopamine D₃ receptor agonists. ACS Chem.Neurosci. 2017 PMID: 27801563

Product Documents for SK 609