Chemical Name: 5-Methylnaphth[2,1-d]oxazol-2-amine
Biological ActivitySKA 121 is a positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.
Coleman et al.
Vascular reactivity profile of novel KCa 3.1-selective positive-gating modulators in the coronary vascular bed.
Oliván-Viguera et al.
Basic Clin.Pharmacol.Toxicol., 2016;119:184
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