SKA 31

Tocris Bioscience | Catalog # 3670

KCa3.1 (IK) and KCa2 (SK) channel activator
Tocris Bioscience

Key Product Details

Description

KCa3.1 (IK) and KCa2 (SK) channel activator
View all Ca2+-Activated Potassium Channel Activators »

Product Description

SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

Product Specifications for SKA 31

Molecular Weight

200.26

Formula

C11H8N2S

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

Naphtho[1,2-d]thiazol-2-ylamine

CAS Number

40172-65-4

PubChem ID

94880

InChI Key

FECQXVPRUCCUIL-UHFFFAOYSA-N

SMILES

NC3=NC2=C(S3)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.03 100
Ethanol 20.03 100

Preparing Stock Solutions for SKA 31

The following data is based on the product molecular weight 200.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.99 mL 24.97 mL 49.94 mL
5 mM 1.00 mL 4.99 mL 9.99 mL
10 mM 0.50 mL 2.50 mL 4.99 mL
50 mM 0.10 mL 0.50 mL 1.00 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for SKA 31

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKA 31

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for SKA 31 (1)

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  • SKA 31 is a great channel activator and works well on biological lab conditions
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2018
    Great product for studies on Kca channel opening as a measure to compare between other activators. Would use again and suggest to others.
    SKA 31 3670

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