Chemical Name: Naphtho[1,2-d]thiazol-2-ylamine
Biological ActivityActivator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.
Sankaranarayanan et al.
Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.
Brahler et al.
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Reviews for SKA 31
Average Rating: 5 (Based on 1 Review)
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Great product for studies on Kca channel opening as a measure to compare between other activators. Would use again and suggest to others.