(+)-SK&F 10047 hydrochloride
Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
Biological ActivityPrototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
(+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ1 sites.
Kamei et al.
Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats.
Matsuno et al.
Brain Res., 1995;690:200
Sigma receptors: biology and function.
Walker et al.
Citations for (+)-SK&F 10047 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:
5 Citations: Showing 1 - 5
Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors.
Authors: Brailoiu Et al.
Cell Rep 2019;26:330
The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
Authors: Kasaharaa Et al.
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
Authors: Rodríguez-Muñoz Et al.
Int J Neuropsychopharmacol 2015;6:35458
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
PLoS One 2014;17:1943
Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands.
Authors: Amer Et al.
Br J Pharmacol 2013;168:1445
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