Catalog Number: 1079
Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
Biological Activity
Prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.
Technical Data
  • M.Wt:
    293.84
  • Formula:
    C17H23NO.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    133005-41-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated σ1 sites.
    Kamei et al.
    Eur.J.Pharmacol., 1996;309:149
  2. Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats.
    Matsuno et al.
    Brain Res., 1995;690:200
  3. Sigma receptors: biology and function.
    Walker et al.
    Pharmacol.Rev., 1990;42:355
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
    Authors: Kasaharaa Et al.
    Neuroscience 2016;340:176
  2. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol 2015;6:35458
  3. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    PLoS One 2014;17:1943

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