SKF 86002 dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:2008
Chemical Name:6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
Inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.
Technical Data
  • M.Wt:
    370.27
  • Formula:
    C16H12FN3S.2HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    116339-68-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 86002 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
    Authors: Haas Et al.
    PLoS Pathog  2013;9:e1003737

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