Catalog Number: 2008
Chemical Name: 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride
Biological Activity
Inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
    Griswold et al.
    Biochem.Pharmacol., 1987;36:3463
  2. A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis.
    Lee et al.
    Nature, 1994;372:739
  3. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
    Nick et al.
    J.Clin.Invest., 1997;99:975

The citations listed below are publications that use Tocris products. Selected citations for SKF 86002 dihydrochloride include:

Showing Results 1 - 1 of 1

  1. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
    Authors: Haas Et al.
    PLoS Pathog
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