Inhibitor of p38 MAP kinase (IC50
= 0.1 - 1 μ
M). Potently inhibits LPS-induced IL-1 and TNF-α
production in human monocytes (IC50
= 1 μ
M). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50
values are 10 and 100 μ
M respectively). Anti-inflammatory following oral administration in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
Griswold et al.
A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis.
Lee et al.
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
Nick et al.
The citations listed below are publications that use Tocris products. Selected citations for SKF 86002 dihydrochloride include:
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