SKF 86002 dihydrochloride

Key Product Details

Product Description

Inhibitor of p38 MAP kinase (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC₅₀ values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.

Product Specifications for SKF 86002 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SKF 86002 dihydrochloride

The following data is based on the product molecular weight 370.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.40 mL	27.01 mL	54.01 mL
2.5 mM	1.08 mL	5.40 mL	10.80 mL
5 mM	0.54 mL	2.70 mL	5.40 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5711 publications citing the usage of this product.

• Lee A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis. Nature 1994 PMID: 7997261
• Nick Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J.Clin.Invest. 1997 PMID: 9062356
• Griswold SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem.Pharmacol. 1987 PMID: 2823821

Product Documents for SKF 86002 dihydrochloride