SKF 86466 hydrochloride
Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
Biological ActivitySKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
Roesler et al.
An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males.
Schafers et al.
Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity.
Hieble et al.
Citation for SKF 86466 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SKF 86466 hydrochloride include:
1 Citation: Showing 1 - 1
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Authors: Zeltner Et al.
Nat Med 2016;22:1421
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Great for passaging hPSCs with dissociation into single cells with 10 μM.