SKF 86466 hydrochloride
Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
Purity: ≥98%
Biological Activity
SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
Roesler et al.
J.Pharmacol.Exp.Ther., 1986;236:1 -
An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males.
Schafers et al.
Br.J.Clin.Pharmacol., 1990;30:884 -
Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity.
Hieble et al.
J.Pharmacol.Exp.Ther., 1985;236:90
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Citation for SKF 86466 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SKF 86466 hydrochloride include:
1 Citation: Showing 1 - 1
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Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Authors: Zeltner Et al.
Nat Med 2016;22:1421
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Great for passaging hPSCs with dissociation into single cells with 10 μM.
