SKF 86466 hydrochloride

Catalog # Availability Size / Price Qty
SKF 86466 hydrochloride | CAS No. 86129-54-6 | Adrenergic alpha-2 Receptor Antagonists
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Description: Potent and selective α2 antagonist

Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products

Biological Activity

SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia
    N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer
    Nat. Med., 2016;22(12):1421-1427.
  2. Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
    Roesler et al.
    J.Pharmacol.Exp.Ther., 1986;236:1
  3. An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males.
    Schafers et al.
    Br.J.Clin.Pharmacol., 1990;30:884

Product Datasheets

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Citation for SKF 86466 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SKF 86466 hydrochloride include:

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