SKF 86466 hydrochloride

Tocris Bioscience | Catalog # 3866

Potent and selective α2 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective α2 antagonist
View all Adrenergic alpha-2 Receptor Antagonists »

Product Description

SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Product Specifications for SKF 86466 hydrochloride

Molecular Weight

232.15

Formula

C11H14ClN.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride

CAS Number

86129-54-6

PubChem ID

10220250

InChI Key

JKQKVNMNAIFCFS-UHFFFAOYSA-N

SMILES

CN2CCC1=CC=CC(Cl)=C1CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.21 100
DMSO 23.21 100

Preparing Stock Solutions for SKF 86466 hydrochloride

The following data is based on the product molecular weight 232.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.31 mL 21.54 mL 43.08 mL
5 mM 0.86 mL 4.31 mL 8.62 mL
10 mM 0.43 mL 2.15 mL 4.31 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SKF 86466 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKF 86466 hydrochloride

For research use only

Citations for SKF 86466 hydrochloride

Customer Reviews for SKF 86466 hydrochloride (1)

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  • Worked great and at a nice price.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human PSC
    Verified Customer | Posted 06/30/2020
    Great for passaging hPSCs with dissociation into single cells with 10 μM.
    SKF 86466 hydrochloride 3866

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