Potent and selective α2
antagonist at pre- and post-junctional α2
values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
Roesler et al.
An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males.
Schafers et al.
Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity.
Hieble et al.