Catalog Number: 3866
Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
Biological Activity
Potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat.
    Roesler et al.
    J.Pharmacol.Exp.Ther., 1986;236:1
  2. An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males.
    Schafers et al.
    Br.J.Clin.Pharmacol., 1990;30:884
  3. Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity.
    Hieble et al.
    J.Pharmacol.Exp.Ther., 1985;236:90
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