SKF 89976A hydrochloride

Key Product Details

Product Description

SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1 (IC₅₀ values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K_i = 7 μM) and transmitter-gated current non-competitively (K_i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for SKF 89976A hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SKF 89976A hydrochloride

The following data is based on the product molecular weight 371.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.44 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Krause and Schwarz Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1. Mol.Pharmacol. 2005 PMID: 16150932
• Murali Dha On the bioactive conformation of the GABA uptake inhibitor SK&F 89976-A. Bioorg.Med.Chem.Lett.
• Ali Orally active and potent inhibitors of γ-aminobutyric acid. J.Med.Chem. 1985 PMID: 2985785

Product Documents for SKF 89976A hydrochloride