Chemical Name:1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Biological Activity A potent GABA uptake inhibitor, selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo.
Soluble to 100 mM in water with gentle warming and to 100 mM in DMSO
Desiccate at +4°C
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