SKF 89976A hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:1081
Chemical Name:1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
A potent GABA uptake inhibitor, selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo.
Technical Data
  • M.Wt:
    371.91
  • Formula:
    C22H25NO2.HCl
  • Solubility:
    Soluble to 100 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    85375-15-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 89976A hydrochloride include:

1 Citations: Showing 1 - 1

  1. Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
    Authors: Sousa Et al.
    Neuropsychopharmacology  2011;36:472

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