SKF 89976A hydrochloride
Chemical Name: 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Biological ActivitySKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Orally active and potent inhibitors of γ-aminobutyric acid.
Ali et al.
Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
Krause and Schwarz
On the bioactive conformation of the GABA uptake inhibitor SK&F 89976-A.
Citation for SKF 89976A hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SKF 89976A hydrochloride include:
1 Citation: Showing 1 - 1
Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
Authors: Sousa Et al.
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