Catalog Number: 0379
Alternate Names: CGP 35024
Chemical Name: 3-Aminopropyl(methyl)phosphinic acid
Biological Activity
Very potent GABAB agonist, at least ten times more active than baclofen (Cat. No. 0417). Also GABAA-ρ antagonist.
Technical Data
  • M.Wt:
    137.12
  • Formula:
    C4H12NO2P
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    127729-35-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro.
    Bon and Galvan
    Br.J.Pharmacol., 1996;118:961
  2. Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
    Froestl et al.
    J.Med.Chem., 1995;38:3297
  3. GABAC receptors: relatively simple transmitter-gated ion channels?
    Johnston
    TiPS, 1996;17:319
  4. Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices.
    Seabrook et al.
    Br.J.Pharmacol., 1990;101:949
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 97541 include:

6 Citations: Showing 1 - 6
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  1. FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor.
    Authors: Lecat-Guillet
    Cell Chem Biol 2017;24(3):360
  2. Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.
    Authors: Ignell Et al.
    Br J Pharmacol 2009;106:13070
  3. A presynaptic gain control mechanism fine-tunes olfactory behavior.
    Authors: Root Et al.
    Neuron 2008;59:311
  4. Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice.
    Authors: Chen Et al.
    Mol Pain 2008;4:41
  5. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol 2004;142:1038
  6. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    Mol Pain 2000;131:1050

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