SKF 97541

Tocris Bioscience | Catalog # 0379

Highly potent GABAB agonist; also GABAA-ρ antagonist
Tocris Bioscience

Key Product Details

Description

Highly potent GABAB agonist; also GABAA-ρ antagonist

Alternative Names

CGP 35024
View all GABA-B Receptor Agonists »

Product Description

SKF 97541 is a potent GABAB agonist (EC50 = 50 nM). SKF 97541 depresses striatal synaptic potentials and hyperpolarizes nigral neurons (EC50 values = 92 nM and 150 nM, respectively). SKF 97541 shows antidepressant effects in animal models and is also a GABAA-ρ antagonist.

Product Specifications for SKF 97541

Molecular Weight

137.12

Formula

C4H12NO2P

Storage

Desiccate at RT

Chemical Name

3-Aminopropyl(methyl)phosphinic acid

CAS Number

127729-35-5

PubChem ID

5230

InChI Key

NHVRIDDXGZPJTJ-UHFFFAOYSA-N

SMILES

NCCCP(O)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.71 100

Preparing Stock Solutions for SKF 97541

The following data is based on the product molecular weight 137.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.29 mL 36.46 mL 72.93 mL
5 mM 1.46 mL 7.29 mL 14.59 mL
10 mM 0.73 mL 3.65 mL 7.29 mL
50 mM 0.15 mL 0.73 mL 1.46 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 52 publications citing the usage of this product.

Product Documents for SKF 97541

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKF 97541

For research use only

Customer Reviews for SKF 97541 (1)

4 out of 5
1 Customer Rating
5 Stars
0%
4 Stars
100%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used SKF 97541?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Test of potential modulation of 5HT-1B receptor effects
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Arcuate nucleus
    Verified Customer | Posted 12/10/2023
    SKF 97541 was used to test a (potential) impact of GABA-B receptors on the effect of 5HT-1B receptors on neurotransmitter vesicle release in interneuronal synapse. Picture: membrane capacitance fluctuation of living neuron after series of electrical stimuli delivered to acute neural tissue. Left: control. Right: activation of GABA-B receptors (with 1 microM SKF 97541), mGlu receptors and ACh receptors do not show a significant effect. Grey traces: individual recordings; red: averaged trace.
    SKF 97541 0379

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All