SKI II

  ( 4 citations )    
Product Datasheet
Catalog Number:2097
Chemical Name:4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Product Details
Citations (4)
Reviews
Biological Activity
Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
Technical Data
  • M.Wt:
    302.78
  • Formula:
    C15H11ClN2OS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    312636-16-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKI II include:

4 Citations: Showing 1 - 4
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  1. Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.
    Authors: Reid Et al.
    Am J Nephrol  2015;4:e61
  2. Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
    Authors: Xun Et al.
    J Exp Clin Cancer Res  2015;34:94
  3. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.
    Authors: Park Et al.
    Am J Physiol Renal Physiol  2012;303:F721
  4. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
    Authors: Kim Et al.
    J Biol Chem  2010;31:353

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