Catalog Number: 2097
Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Biological Activity
Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
Technical Data
  • M.Wt:
    302.78
  • Formula:
    C15H11ClN2OS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    312636-16-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antitumor activity of sphingosine kinase inhibitors.
    French et al.
    J.Pharmacol.Exp.Ther., 2006;318:596
  2. Discovery and evaluation of inhibitors of human sphingosine kinase.
    French et al.
    Cancer Res., 2003;63:5862
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKI II include:

3 Citations: Showing 1 - 3
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  1. Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.
    Authors: Reid Et al.
    Am J Nephrol 2015;4:e61
  2. Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
    Authors: Xun Et al.
    J Exp Clin Cancer Res 2015;34:94
  3. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
    Authors: Kim Et al.
    J Biol Chem 2010;31:353

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