SKI II

Catalog # Availability Size / Price Qty
2097/10
2097/50
SKI II | CAS No. 312636-16-1 | Sphingosine Kinase Inhibitors
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Description: Selective non-lipid inhibitor of sphingosine kinase

Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

Purity: ≥98%

Product Details
Citations (6)
Reviews

Biological Activity

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).

Technical Data

M.Wt:
302.78
Formula:
C15H11ClN2OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
312636-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumor activity of sphingosine kinase inhibitors.
    French et al.
    J.Pharmacol.Exp.Ther., 2006;318:596
  2. Discovery and evaluation of inhibitors of human sphingosine kinase.
    French et al.
    Cancer Res., 2003;63:5862

Product Datasheets

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Citations for SKI II

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