SKI II

Key Product Details

Product Description

SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC₅₀ = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC₅₀ = 0.9 - 4.6 μM).

Product Specifications for SKI II

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SKI II

The following data is based on the product molecular weight 302.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.30 mL	16.51 mL	33.03 mL
5 mM	0.66 mL	3.30 mL	6.61 mL
10 mM	0.33 mL	1.65 mL	3.30 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

• French Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res.
• French Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 2006 PMID: 16632640

Product Documents for SKI II