Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Biological ActivitySKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumor activity of sphingosine kinase inhibitors.
French et al.
Discovery and evaluation of inhibitors of human sphingosine kinase.
French et al.
Cancer Res., 2003;63:5862
Citations for SKI II
The citations listed below are publications that use Tocris products. Selected citations for SKI II include:
6 Citations: Showing 1 - 6
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Authors: Seong Et al.
Cancer Res 2017;77:696
Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.
Authors: Reid Et al.
Am J Nephrol 2015;4:e61
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
Authors: Xun Et al.
J Exp Clin Cancer Res 2015;34:94
The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes.
Authors: Minashima Et al.
Osteoarthritis Cartilage 2014;22:852
A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.
Authors: Park Et al.
Am J Physiol Renal Physiol 2012;303:F721
Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
Authors: Kim Et al.
J Biol Chem 2010;31:353
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