Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1
/S cell cycle arrest in T47D cells and LNCaP cells; induces G2
/M cell cycle arrest in MCF-7 cells.
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation.
Rico-Bautista and Wolf
Specific small molecule inhibitors of Skp2-mediated p27 degradation.
Wu et al.