Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Biological ActivityInhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation.
Rico-Bautista and Wolf
Specific small molecule inhibitors of Skp2-mediated p27 degradation.
Wu et al.
Citation for SKPin C1
The citations listed below are publications that use Tocris products. Selected citations for SKPin C1 include:
1 Citation: Showing 1 - 1
Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.
Authors: Kramer Et al.
J Neurosci 2016;36:10425
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