Catalog Number: 4817
Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Biological Activity
Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
Technical Data
  • M.Wt:
    465.34
  • Formula:
    C18H13BrN2O4S2
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    432001-69-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation.
    Rico-Bautista and Wolf
    Chem.Biol., 2012;19:1497
  2. Specific small molecule inhibitors of Skp2-mediated p27 degradation.
    Wu et al.
    Chem.Biol., 2012;19:1515

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