SKPin C1

Catalog # Availability Size / Price Qty
SKPin C1 | CAS No. 432001-69-9 | Ubiquitin Ligase (E3) Inhibitors
1 Image
Description: Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid

Purity: ≥98%

Product Details
Citations (2)

Biological Activity

SKPin C1 is an inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.

Technical Data

Soluble to 10 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation.
    Rico-Bautista and Wolf
    Chem.Biol., 2012;19:1497
  2. Specific small molecule inhibitors of Skp2-mediated p27 degradation.
    Wu et al.
    Chem.Biol., 2012;19:1515

Product Datasheets

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Citations for SKPin C1

The citations listed below are publications that use Tocris products. Selected citations for SKPin C1 include:

2 Citations: Showing 1 - 2


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