Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Biological ActivityInhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation.
Rico-Bautista and Wolf
Specific small molecule inhibitors of Skp2-mediated p27 degradation.
Wu et al.
Citations for SKPin C1
The citations listed below are publications that use Tocris products. Selected citations for SKPin C1 include:
2 Citations: Showing 1 - 2
Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer.
Authors: Brough Et al.
Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.
Authors: Kramer Et al.
J Neurosci 2016;36:10425
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