Catalog Number: 1468
Biological Activity
Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in mice in vivo.

Control Peptide also available.

Technical Data
  • M.Wt:
    656.82
  • Formula:
    C29H56N10O7
  • Sequence:
    SLIGRL

    (Modifications: Leu-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    171436-38-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle.
    Al-Ani et al.
    Can.J.Physiol.Pharmacol., 1995;73:1203
  2. In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse.
    Kawabata et al.
    Br.J.Pharmacol., 2001;133:1213
  3. Molecular cloning of a potential proteinase activated receptor.
    Nystedt et al.
    Proc.Natl.Acad.Sci.U.S.A., 1994;91:9208
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SLIGRL-NH2 include:

5 Citations: Showing 1 - 5
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  1. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci 2014;55:3912
  2. Protease activated receptor-2 contributes to heart failure.
    Authors: Antoniak Et al.
    EMBO J 2013;8:e81733
  3. TRPV1-lineage neurons are required for thermal sensation.
    Authors: Mishra Et al.
    PLoS One 2011;30:582
  4. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
    Authors: Vellani Et al.
    Mol Pain 2010;6:61
  5. Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells.
    Authors: Vidwan Et al.
    Arterioscler Thromb Vasc Biol 2010;30:2587
Tocris Peptides
Description Application Cat# Citations Images  

LRGILS-NH2

3394  
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