SLM 6031434 hydrochloride

Catalog # Availability Size / Price Qty
6281/50
6281/10
Cat.No. 6281 - SLM 6031434 hydrochloride | C22H30F3N5O2.HCl | CAS No. 1897379-34-8
1 Image
Description: Selective sphingosine kinase 2 (Sphk2) inhibitor

Chemical Name: (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride

Purity: ≥98%

Product Details
Reviews

Biological Activity

Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.

Technical Data

M.Wt:
489.96
Formula:
C22H30F3N5O2.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1897379-34-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the University of Virginia Patent Foundation

Background References

  1. Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels.
    Kharel et al.
    J.Pharmacol.Exp.Ther., 2015;355:23

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SLM 6031434 hydrochloride

There are currently no reviews for this product. Be the first to review SLM 6031434 hydrochloride and earn rewards!

Have you used SLM 6031434 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.