SLM 6031434 hydrochloride

Key Product Details

Product Description

SLM 6031434 hydrochloride is a Sphk2 inhibitor (K_i = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Product Specifications for SLM 6031434 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SLM 6031434 hydrochloride

The following data is based on the product molecular weight 489.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.20 mL	20.41 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Schwalm Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal. 2021 PMID: 33301900
• Kharel Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 2015 PMID: 26243740

Product Documents for SLM 6031434 hydrochloride