SLM 6031434 hydrochloride
Chemical Name: (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride
Biological ActivitySLM 6031434 hydrochloride is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels.
Kharel et al.
Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis.
Schwalm et al.
Cell Signal., 2021;79
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