SLPI Antibody (31)

Novus Biologicals | Catalog # NBP1-42437

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Western Blot, ELISA, Immunoassay, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 31
View all SLPI Primary Antibodies »

Product Specifications

Immunogen

SLPI purified from sputum

Specificity

The antibody reacts specificly with secretory leukocyte proteinase inhibitor (SLPI; also known as antileukoprotease (ALP)).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for SLPI Antibody (31)

Western Blot: SLPI Antibody (31) [NBP1-42437]

Western Blot: SLPI Antibody (31) [NBP1-42437]

Western Blot: SLPI Antibody (31) [NBP1-42437] - 1. Recombinant SLPI 100 ng/ml, non-boiled 2. BAL (COPD) non boiled.
Immunohistochemistry-Frozen: SLPI Antibody (31) [NBP1-42437]

Immunohistochemistry-Frozen: SLPI Antibody (31) [NBP1-42437]

Immunohistochemistry-Frozen: SLPI Antibody (31) [NBP1-42437] - Human tonsil frozen sections

Applications for SLPI Antibody (31)

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Immunoprecipitation

1:10-1:500

Western Blot

1:100-1:2000
Application Notes
It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: SLPI

SLPI is a 11.7 kDa cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs and by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).

Long Name

Secretory Leukocyte Protease Inhibitor

Alternate Names

ALK1, ALPProtease inhibitor WAP4, antileukoproteinase, BLPISeminal proteinase inhibitor, HUSI, HUSI-I, Mucus proteinase inhibitor, secretory leukocyte peptidase inhibitor, Secretory leukocyte protease inhibitor, secretory leukocyte protease inhibitor (antileukoproteinase), WAP four-disulfide core domain protein 4, WAP4HUSI-1, WFDC4MPI

Gene Symbol

SLPI

Additional SLPI Products

Product Documents for SLPI Antibody (31)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for SLPI Antibody (31)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for SLPI Antibody (31)

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  • Q: We would like to order SLPi antibody (NBP1-42437). This product is recommended for detection of SLPI of human and rat origin. Can you provide me the info about the antigen used for Ab production? Did you test this product in rat? Or it is only a prediction due to sequence homology between species? If so, can you give me some reference for it?

    A: The immunogen for this antibody is SLPI purified from sputum. Rat cross reactivity is based on sequence homology.

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