SNC 80 (CAS 156727-74-1): R&D Systems
Catalog Number: 0764
Chemical Name: (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Biological Activity
A highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. HCl with gentle warming and to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist.
    Bilsky et al.
    J.Pharmacol.Exp.Ther., 1995;273:359
  2. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid
    Calderon et al.
    J.Med.Chem., 1994;37:2125
  3. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
    Knapp et al.
    J.Pharmacol.Exp.Ther., 1996;277:1284

The citations listed below are publications that use Tocris products. Selected citations for SNC 80 include:

9 Citations: Showing 1 - 9
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  1. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
    Authors: Levoye Et al.
    Brain Struct Funct 2015;6:167
  2. A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.
    Authors: Erbs Et al.
    J Neurosci 2015;220:677
  3. Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
    Authors: Schuster Et al.
    Transl Oncol 2015;172:642
  4. Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
    Authors: Ong Et al.
    Front Endocrinol (Lausanne) 2015;172:615
  5. δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.
    Authors: Pradhan Et al.
    Br J Pharmacol 2014;171:2375
  6. Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
    Authors: Burbassi Et al.
    Eur J Neurosci 2010;32:1278
  7. N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface.
    Authors: Markkanen and Petäjä-Repo
    J Biol Chem 2008;283:29086
  8. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.
    Authors: Scherrer Et al.
    Proc Natl Acad Sci U S A 2006;103:9691
  9. Heterodimerization of μ and δ opioid receptors: A role in opiate synergy.
    Authors: Gomes Et al.
    Br J Pharmacol 2000;20:RC110

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