Chemical Name: (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Biological ActivitySNC 80 is a highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist.
Bilsky et al.
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
Knapp et al.
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid
Calderon et al.
Citations for SNC 80
The citations listed below are publications that use Tocris products. Selected citations for SNC 80 include:
18 Citations: Showing 1 - 10
Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice.
Authors: Robins Et al.
Front Psychiatry 2018;9:112
Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
Authors: Wang Et al.
Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.
A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
Authors: Levoye Et al.
Brain Struct Funct 2015;6:167
A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.
Authors: Erbs Et al.
J Neurosci 2015;220:677
Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
Authors: Schuster Et al.
Transl Oncol 2015;172:642
Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking.
Authors: Ong Et al.
Front Endocrinol (Lausanne) 2015;172:615
The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.
Authors: Neumann Et al.
J Invest Dermatol 2015;135:471
δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.
Authors: Pradhan Et al.
Br J Pharmacol 2014;171:2375
Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism.
Authors: Milan-Lobo Et al.
PLoS One 2013;8:e58362
Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
Authors: Burbassi Et al.
Eur J Neurosci 2010;32:1278
The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects.
Authors: Butelman Et al.
Psychopharmacology (Berl) 2010;210:253
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Authors: Pacheco Et al.
Br J Pharmacol 2009;158:225
N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface.
Authors: Markkanen and Petäjä-Repo
J Biol Chem 2008;283:29086
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Authors: Pacheco Et al.
Br J Pharmacol 2008;154:1143
Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.
Authors: Scherrer Et al.
Proc Natl Acad Sci U S A 2006;103:9691
Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists.
Authors: Sluka Et al.
J Pharmacol Exp Ther 2002;302:1146
Heterodimerization of μ and δ opioid receptors: A role in opiate synergy.
Authors: Gomes Et al.
Br J Pharmacol 2000;20:RC110
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