SNC 80

  ( 14 citations )    
Product Datasheet
Catalog Number:0764
Chemical Name:(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
A highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.
Technical Data
  • M.Wt:
    449.64
  • Formula:
    C28H39N3O2
  • Solubility:
    Soluble to 100 mM in 1eq. HCl with gentle warming and to 20 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    156727-74-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SNC 80 include:

14 Citations: Showing 1 - 10
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  1. Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.
    Authors: Ye
    Neuroscience  2017;363:50
  2. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
    Authors: Levoye Et al.
    Brain Struct Funct  2015;6:167
  3. A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.
    Authors: Erbs Et al.
    J Neurosci  2015;220:677
  4. Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
    Authors: Schuster Et al.
    Transl Oncol  2015;172:642
  5. Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
    Authors: Ong Et al.
    Front Endocrinol (Lausanne)  2015;172:615
  6. The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.
    Authors: Neumann Et al.
    J Invest Dermatol  2015;135:471
  7. δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.
    Authors: Pradhan Et al.
    Br J Pharmacol  2014;171:2375
  8. Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
    Authors: Burbassi Et al.
    Eur J Neurosci  2010;32:1278
  9. The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects.
    Authors: Butelman Et al.
    Psychopharmacology (Berl)  2010;210:253
  10. Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
    Authors: Pacheco Et al.
    Br J Pharmacol  2009;158:225
  11. N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface.
    Authors: Markkanen and Petäjä-Repo
    J Biol Chem  2008;283:29086
  12. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.
    Authors: Scherrer Et al.
    Proc Natl Acad Sci U S A  2006;103:9691
  13. Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists.
    Authors: Sluka Et al.
    J Pharmacol Exp Ther  2002;302:1146
  14. Heterodimerization of μ and δ opioid receptors: A role in opiate synergy.
    Authors: Gomes Et al.
    Br J Pharmacol  2000;20:RC110
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