Selective, high affinity antagonist for the rat and human dopamine D4
= 10 nM). Exhibits low affinity at other monoamine receptors (Ki
> 2000 nM). Induces c-fos
gene expression in medial prefrontal cortex in a similar manner to clozapine
(Cat. No. 0444). Brain penetrant and orally available.
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Sold for research purposes under agreement from Pfizer Inc.
Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.
Merchant et al.