Sonepiprazole

Catalog # Availability Size / Price Qty
4185/10
4185/50
Sonepiprazole | CAS No. 170858-33-0 | Dopamine D4 Receptor Antagonists
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Description: Selective D4 antagonist
Alternative Names: PNU 101387, U 101387

Chemical Name: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

Selective, high affinity antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM). Exhibits low affinity at other monoamine receptors (Ki > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.

Technical Data

M.Wt:
401.52
Formula:
C21H27N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
170858-33-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Pharmacological characterization of U-101387, a DA D4 receptor selective antagonist.
    Merchant et al.
    J.Pharm.Exp.Ther., 1996;279:1392

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