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Clozapine | CAS No. 5786-21-0 | Non-selective Dopamine Receptor Antagonists
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Description: Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist

Chemical Name: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Purity: ≥99%

Product Details
Citations (20)
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Biological Activity

Clozapine is an atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively).

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in 2eq.HCl with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Clozapine

The citations listed below are publications that use Tocris products. Selected citations for Clozapine include:

20 Citations: Showing 1 - 10

  1. Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons.
    Authors: Maldonado Et al.
    Curr Biol  2021;31:322
  2. A projection from the paraventricular nucleus of the thalamus to the shell of the nucleus accumbens contributes to footshock stress-induced social avoidance
    Authors: Dong Et al.
    Neurobiol Stress  2020;13
  3. Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs.
    Authors: Joshi and Panicker
    Eneuro  2019;5
  4. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
    Authors: Peng Et al.
    Cell  2018;172:719
  5. Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits.
    Authors: Cui Et al.
    Mol Brain  2016;9:89
  6. The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits intranslational models of cognitive symptoms associated with schizophrenia
    Authors: Griebel Et al.
    Scientific Reports  2016;6:35320
  7. Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid.
    Authors: Larsson Et al.
    Brain Res  2015;8:49
  8. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
    Authors: Canfrán-Duque Et al.
    Int J Tryptophan Res  2015;10:e0141829
  9. Pramipexole reduces phosphorylation of α-synuclein at serine-129.
    Authors: Chau Et al.
    Exp Mol Med  2013;51:573
  10. Age-dependent regulation of synaptic connections by DA D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627
  11. D4 DA receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1.
    Authors: Herwerth Et al.
    Cereb Cortex  2012;22:1786
  12. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
    Authors: Kurita Et al.
    Nat Neurosci  2012;15:1245
  13. Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.
    Authors: Hillenmeyer Et al.
    Genome Biol  2010;11:R30
  14. Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk.
    Authors: Oliver and Davies
    Hum Mol Genet  2009;18:4576
  15. Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, cloz. and MDL 100907.
    Authors: Singh Et al.
    Int J Neuropsychopharmacol  2009;12:651
  16. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation.
    Authors: Magliaro and Saldanha
    Brain Res  2009;1283:14
  17. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
    Authors: Balu Et al.
    J Mol Neurosci  2008;1211:37
  18. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
    Authors: Hampson Et al.
    Diabetologia  2007;50:1743
  19. Haloperidol and cloz. differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex.
    Authors: Roh Et al.
    Front Cell Neurosci  2007;39:353
  20. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-MthD.-aspartate receptor activity.
    Authors: Sur Et al.
    Proc Natl Acad Sci U S A  2003;100:13674


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