Spadin

Catalog # Availability Size / Price Qty
5594/1

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Spadin
1 Image
Description: Potent K2P2.1 (TREK-1) channel blocker

Purity: ≥95%

Product Details
Citations (1)
Reviews

Biological Activity

Spadin is a potent TREK-1 channel blocker (IC50 = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant.

Technical Data

M.Wt:
2012.34
Formula:
C96H142N26O22
Sequence:
YAPLPRWSGPIGVSWGLR
Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1270083-24-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for Spadin

The citations listed below are publications that use Tocris products. Selected citations for Spadin include:

1 Citation: Showing 1 - 1

FAQs

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