Catalog Number: 5594
Biological Activity
Potent TREK-1 channel blocker (IC50 = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant.
Technical Data
  • M.Wt:
    2012.34
  • Formula:
    C96H142N26O22
  • Sequence:
    YAPLPRWSGPIGVSWGLR
  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    1270083-24-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept.
    Borsotto et al.
    Br.J.Pharmacol., 2015;172:771
  2. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.
    Mazella et al.
    PLoS Biol., 2010;8:e1000355

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